SUNG CHUN LAB Computational genetics of respiratory diseases at Boston Children's Hospital

Publications

2023

  1. Hecker J, Chun S, Samiei A, Liu C, Laurie C, Kachroo P, Lutz SM, Lee S, Smith AV, Lasky-Su J, Cho MH, Sharma S, Soto Quirós ME, Avila L, Celedón JC, Raby B, Zhou X, Silverman EK, DeMeo DL, Lange C, Weiss ST. FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies. Hum Mol Genet. 2023 Jan 27;32(4):696-707.
    [ doi: 10.1093/hmg/ddac258 ] [ PMID: 36255742 ] [ PMCID: PMC9896483 ]
  2. Queen K, Nguyen MN, Chun S, Gilliland FD, Raby B, Millstein J. ACDC: a general approach for detecting phenotype or exposure associated co-expression. Frontiers in Medicine. 2023 May 19;10:1118824.
    [ doi: 10.3389/fmed.2023.1118824 ] [ PMID: 37275375 ] [ PMCID: PMC10235619 ]
  3. Hayeck TJ, Busby GB, Chun S, Lewis ACF, Roberts MC, Vilhjalmsson BJ. Polygenic Risk Scores: Genomes to Risk Prediction. Clinical Chemistry. Volume 69, Issue 6, June 2023, Pages 551–557.
    [ doi: 10.1093/clinchem/hvad049 ] [ PMID: 37232050 ]

2022

  1. Chun S*, Akle S*, Teodosiadis A, Cade BE, Wang H, Sofer T, Evans DS, Stone KL, Gharib SA, Mukherjee S, Palmer LJ, Hillman D, Rotter JI, Hanis CL, Stamatoyannopoulos JA, Redline S, Cotsapas C, Sunyaev SR. Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits. PLoS Genet. 2022 Dec;18(12):e1010557.
    [ doi: 10.1371/journal.pgen.1010557 ] [ PMID: 36574455 ] [ PMCID: PMC9829185 ]
  2. Connally NJ, Nazeen S, Lee D, Shi H, Stamatoyannopoulos J, Chun S, Cotsapas C, Cassa CA, Sunyaev SR. The missing link between genetic association and regulatory function. Elife. 2022 Dec 14;11.
    [ doi: 10.7554/eLife.74970 ] [ PMID: 36515579 ] [ PMCID: PMC9842386 ]

2021

  1. Gasperi C, Chun S, Sunyaev SR, Cotsapas C. Shared associations identify causal relationships between gene expression and immune cell phenotypes. Commun Biol. 2021 Mar 4;4(1):279.
    [ doi: 10.1038/s42003-021-01823-w ] [ PMID: 33664438 ] [ PMCID: PMC7933159 ]
  2. Bhak Y, Jeon Y, Jeon S, Yoon C, Kim M, Blazyte A, Kim Y, Kang Y, Kim C, Lee SY, Bae JW, Kim W, Kim YJ, Shim J, Kim N, Chun S, Kim BC, Kim BC, Lee S, Bhak J, Shin ES. Polygenic risk score validation using Korean genomes of 265 early-onset acute myocardial infarction patients and 636 healthy controls. PLoS One. 2021;16(2):e0246538.
    [ doi: 10.1371/journal.pone.0246538 ] [ PMID: 33539413 ] [ PMCID: PMC7861392 ]

2020

  1. Chun S*, Imakaev M*, Hui D, Patsopoulos NA, Neale BM, Kathiresan S, Stitziel NO, Sunyaev SR. Non-parametric Polygenic Risk Prediction via Partitioned GWAS Summary Statistics. Am J Hum Genet. 2020 Jul 2;107(1):46-59.
    [ doi: 10.1016/j.ajhg.2020.05.004 ] [ PMID: 32470373 ] [ PMCID: PMC7332650 ]

2018

  1. Chen H, Cade BE, Gleason KJ, Bjonnes AC, Stilp AM, Sofer T, Conomos MP, Ancoli-Israel S, Arens R, Azarbarzin A, Bell GI, Below JE, Chun S, Evans DS, Ewert R, Frazier-Wood AC, Gharib SA, Haba-Rubio J, Hagen EW, Heinzer R, Hillman DR, Johnson WC, Kutalik Z, Lane JM, Larkin EK, Lee SK, Liang J, Loredo JS, Mukherjee S, Palmer LJ, Papanicolaou GJ, Penzel T, Peppard PE, Post WS, Ramos AR, Rice K, Rotter JI, Sands SA, Shah NA, Shin C, Stone KL, Stubbe B, Sul JH, Tafti M, Taylor KD, Teumer A, Thornton TA, Tranah GJ, Wang C, Wang H, Warby SC, Wellman DA, Zee PC, Hanis CL, Laurie CC, Gottlieb DJ, Patel SR, Zhu X, Sunyaev SR, Saxena R, Lin X, Redline S. Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol. 2018 Mar;58(3):391-401.
    [ doi: 10.1165/rcmb.2017-0237OC ] [ PMID: 29077507 ] [ PMCID: PMC5854957 ]

2017

  1. Chun S, Casparino A, Patsopoulos NA, Croteau-Chonka DC, Raby BA, De Jager PL, Sunyaev SR, Cotsapas C. Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types. Nat Genet. 2017 Apr;49(4):600-605.
    [ doi: 10.1038/ng.3795 ] [ PMID: 28218759 ] [ PMCID: PMC5374036 ]

2016

  1. Savova V*, Chun S*, Sohail M*, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA. Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nat Genet. 2016 Mar;48(3):231-237.
    [ doi: 10.1038/ng.3493 ] [ PMID: 26808112 ] [ PMCID: PMC4942303 ]
  2. Cade BE, Chen H, Stilp AM, Gleason KJ, Sofer T, Ancoli-Israel S, Arens R, Bell GI, Below JE, Bjonnes AC, Chun S, Conomos MP, Evans DS, Johnson WC, Frazier-Wood AC, Lane JM, Larkin EK, Loredo JS, Post WS, Ramos AR, Rice K, Rotter JI, Shah NA, Stone KL, Taylor KD, Thornton TA, Tranah GJ, Wang C, Zee PC, Hanis CL, Sunyaev SR, Patel SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline S. Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans. Am J Respir Crit Care Med. 2016 Oct 1;194(7):886-897.
    [ doi: 10.1164/rccm.201512-2431OC ] [ PMID: 26977737 ] [ PMCID: PMC5074655 ]
  3. Cassa CA, Smith SE, Docken W, Hoffman E, McLaughlin H, Chun S, Leshchiner I, Miraoui H, Raychaudhuri S, Frank NY, Wilson BJ, Sunyaev SR, Maas RL, Vuzman D. An argument for early genomic sequencing in atypical cases: a WISP3 variant leads to diagnosis of progressive pseudorheumatoid arthropathy of childhood. Rheumatology (Oxford). 2016 Mar;55(3):586-9.
    [ doi: 10.1093/rheumatology/kev367 ] [ PMID: 26493744 ] [ PMCID: PMC5009447 ]

2015

  1. Francioli LC, Polak PP, Koren A, Menelaou A, Chun S, Renkens I, van Duijn CM, Swertz M, Wijmenga C, van Ommen G, Slagboom PE, Boomsma DI, Ye K, Guryev V, Arndt PF, Kloosterman WP, de Bakker PIW, Sunyaev SR. Genome-wide patterns and properties of de novo mutations in humans. Nat Genet. 2015 Jul;47(7):822-826.
    [ doi: 10.1038/ng.3292 ] [ PMID: 25985141 ] [ PMCID: PMC4485564 ]
  2. Nikolskiy I, Conrad DF, Chun S, Fay JC, Cheverud JM, Lawson HA. Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides. BMC Genomics. 2015 May 28;16:415.
    [ doi: 10.1186/s12864-015-1592-3 ] [ PMID: 26016481 ] [ PMCID: PMC4445795 ]
  3. Akle S, Chun S, Jordan DM, Cassa CA. Mitigating false-positive associations in rare disease gene discovery. Hum Mutat. 2015 Oct;36(10):998-1003.
    [ doi: 10.1002/humu.22847 ] [ PMID: 26378430 ] [ PMCID: PMC4576452 ]

2014

  1. Yim HS, Cho YS, Guang X, Kang SG, Jeong JY, Cha SS, Oh HM, Lee JH, Yang EC, Kwon KK, Kim YJ, Kim TW, Kim W, Jeon JH, Kim SJ, Choi DH, Jho S, Kim HM, Ko J, Kim H, Shin YA, Jung HJ, Zheng Y, Wang Z, Chen Y, Chen M, Jiang A, Li E, Zhang S, Hou H, Kim TH, Yu L, Liu S, Ahn K, Cooper J, Park SG, Hong CP, Jin W, Kim HS, Park C, Lee K, Chun S, Morin PA, O’Brien SJ, Lee H, Kimura J, Moon DY, Manica A, Edwards J, Kim BC, Kim S, Wang J, Bhak J, Lee HS, Lee JH. Minke whale genome and aquatic adaptation in cetaceans. Nat Genet. 2014 Jan;46(1):88-92.
    [ doi: 10.1038/ng.2835 ] [ PMID: 24270359 ] [ PMCID: PMC4079537 ]

2013

  1. Chun S, Plunkett J, Teramo K, Muglia LJ, Fay JC. Fine-mapping an association of FSHR with preterm birth in a Finnish population. PLoS One. 2013;8(10):e78032.
    [ doi: 10.1371/journal.pone.0078032 ] [ PMID: 24205076 ] [ PMCID: PMC3812121 ]

2011

  1. Chun S, Fay JC. Evidence for hitchhiking of deleterious mutations within the human genome. PLoS Genet. 2011 Aug;7(8):e1002240.
    [ doi: 10.1371/journal.pgen.1002240 ] [ PMID: 21901107 ] [ PMCID: PMC3161959 ]

2009

  1. Chun S, Fay JC. Identification of deleterious mutations within three human genomes. Genome Res. 2009 Sep;19(9):1553-61.
    [ doi: 10.1101/gr.092619.109 ] [ PMID: 19602639 ] [ PMCID: PMC2752137 ]

Powered by Jekyll and Poole